Therapeutic class-specific signal detection of bradycardia associated with propranolol hydrochloride

Therapeutic class-specific signal detection of bradycardia associated with propranolol hydrochloride

BACKGROUND Propranolol hydrochloride, one of the most widely used beta-blocker in the treatment of hypertension since 1960s, shows a number of serious and non-serious adverse events. OBJECTIVE Major objectives of this study were to extract the Canadian Adverse Drug Reaction Monitoring Program (CADRMP) database for possible toxic signal detection (SD) of propranolol hydrochloride, evaluate the...

Propranolol hydrochloride

Conductometric determination of propranolol hydrochloride in pharmaceuticals

______________________________________________________________________________ In this paper the conductometric titration of propranolol hydrochloride in pharmaceutical formulations using silver nitrate as titrant is proposed. The method was based on the formation of an insoluble salt (AgCl(s)) between the chloride of propranolol hydrochloride molecule and Ag(I) ions of the titrant AgNO3. The e...

InnoPran XL®(propranolol hydrochloride) Extended Release Capsules

InnoPran XL (propranolol hydrochloride) is a nonselective, beta-adrenergic receptorblocking agent for oral administration, available as an extended release product. InnoPran XL is available as 80 mg and 120 mg capsules which contain sustained-release beads. Each of the beads contains propranolol hydrochloride and is coated with dual membranes. These membranes are designed to retard release of p...

Propranolol Hydrochloride Buccoadhesive Tablet: Development and In-vitro Evaluation

Purposes: Propranolol HCl is a beta blocker commonly used worldwide; however, it shows a low bioavailability due to its extensive first-pass metabolism. To solve this problem, a novel drug delivery system such as buccoadhesive system might be helpful. The aim of the present investigation is to prepare the buccoadhesive tablet of propranolol HCl using different mucoadhesive polymers. Method: Buc...